Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes

The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies. Proteasome activity depends on its catalytic subunits which...

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Dettagli Bibliografici
Pubblicato in:Front Mol Biosci
Autori principali: Schipper-Krom, Sabine, Sanz, Alicia Sanz, van Bodegraven, Emma J., Speijer, Dave, Florea, Bogdan I., Ovaa, Huib, Reits, Eric A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Molecular Biosciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710370/
https://ncbi.nlm.nih.gov/pubmed/31482094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00056
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