Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes

The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies. Proteasome activity depends on its catalytic subunits which...

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Udgivet i:Front Mol Biosci
Main Authors: Schipper-Krom, Sabine, Sanz, Alicia Sanz, van Bodegraven, Emma J., Speijer, Dave, Florea, Bogdan I., Ovaa, Huib, Reits, Eric A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Molecular Biosciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710370/
https://ncbi.nlm.nih.gov/pubmed/31482094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00056
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