Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes

The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies. Proteasome activity depends on its catalytic subunits which...

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Detalles Bibliográficos
Publicado en:Front Mol Biosci
Autores principales: Schipper-Krom, Sabine, Sanz, Alicia Sanz, van Bodegraven, Emma J., Speijer, Dave, Florea, Bogdan I., Ovaa, Huib, Reits, Eric A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Molecular Biosciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710370/
https://ncbi.nlm.nih.gov/pubmed/31482094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00056
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