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Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes

The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies. Proteasome activity depends on its catalytic subunits which...

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Détails bibliographiques
Publié dans:Front Mol Biosci
Auteurs principaux: Schipper-Krom, Sabine, Sanz, Alicia Sanz, van Bodegraven, Emma J., Speijer, Dave, Florea, Bogdan I., Ovaa, Huib, Reits, Eric A.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710370/
https://ncbi.nlm.nih.gov/pubmed/31482094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00056
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