Comprehensive Characterization of the Attenuated Double Auxotroph Mycobacterium tuberculosisΔleuDΔpanCD as an Alternative to H37Rv

Although currently available model organisms such as Mycobacterium smegmatis and Mycobacterium bovis Bacillus Calmette-Guérin (BCG) have significantly contributed to our understanding of tuberculosis (TB) biology, these models have limitations such as differences in genome size, growth rates and vir...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Mouton, Jomien M., Heunis, Tiaan, Dippenaar, Anzaan, Gallant, James L., Kleynhans, Léanie, Sampson, Samantha L.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710366/
https://ncbi.nlm.nih.gov/pubmed/31481950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.01922
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