Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y(2) internalization in alveolar epithelial cells

Bacterial pneumonia is a global health challenge that causes up to 2 million deaths each year. Purinergic signaling plays a pivotal role in healthy alveolar epithelium. Here, we used fluorophore-based analysis and live-cell calcium imaging to address the question of whether the bacterial pathogen St...

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Udgivet i:J Biol Chem
Main Authors: Olotu, Cynthia, Lehmensiek, Felix, Koch, Bastian, Kiefmann, Martina, Riegel, Ann-Kathrin, Hammerschmidt, Sven, Kiefmann, Rainer
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709641/
https://ncbi.nlm.nih.gov/pubmed/31289122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007236
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