IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca(2+) uptake during hypocapnia

In adult respiratory distress syndrome (ARDS) pulmonary perfusion failure increases physiologic dead-space (V(D)/V(T)) correlating with mortality. High V(D)/V(T) results in alveolar hypocapnia, which has been demonstrated to cause edema formation, atelectasis, and surfactant depletion, evoked, at le...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kiefmann, Martina, Tank, Sascha, Keller, Paula, Börnchen, Christian, Rinnenthal, Jan L, Tritt, Marc-Oliver, Schulte-Uentrop, Leonie, Olotu, Cynthia, Goetz, Alwin E, Kiefmann, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596584/
https://ncbi.nlm.nih.gov/pubmed/28837149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.403
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