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CD44 inhibits α-SMA gene expression via a novel G-actin/MRTF-mediated pathway that intersects with TGFβR/p38MAPK signaling in murine skin fibroblasts
Well-regulated differentiation of fibroblasts into myofibroblasts (MF) is critical for skin wound healing. Neoexpression of α-smooth muscle actin (α-SMA), an established marker for MF differentiation, is driven by TGFβ receptor (TGFβR)–mediated signaling. Hyaluronan (HA) and its receptor CD44 may al...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6709637/ https://ncbi.nlm.nih.gov/pubmed/31285260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007834 |
| Oznake: |
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