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In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

Patients with fatty liver diseases present altered mitochondrial morphology and impaired metabolic function. Mitochondrial dynamics and related cell function require the uncleaved form of the dynamin-like GTPase OPA1. Stabilization of OPA1 might then confer a protective mechanism against stress-indu...

詳細記述

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書誌詳細
出版年:J Biol Chem
主要な著者: Li, Lingzi, Martin-Levilain, Juliette, Jiménez-Sánchez, Cecilia, Karaca, Melis, Foti, Michelangelo, Martinou, Jean-Claude, Maechler, Pierre
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709633/
https://ncbi.nlm.nih.gov/pubmed/31285263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007601
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