Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD), extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological intracellular tau (the product of the gene microtubule-associated protein tau (MAPT)). To our knowledge, current...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Saito, Takashi, Mihira, Naomi, Matsuba, Yukio, Sasaguri, Hiroki, Hashimoto, Shoko, Narasimhan, Sneha, Zhang, Bin, Murayama, Shigeo, Higuchi, Makoto, Lee, Virginia M. Y., Trojanowski, John Q., Saido, Takaomi C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709628/
https://ncbi.nlm.nih.gov/pubmed/31273083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009487
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