Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [(18)F]MK6240 in human subjects

PURPOSE: [(18)F]MK6240 was developed for PET imaging of tau aggregates which are implicated in Alzheimer’s disease. The goal of this work was to evaluate the kinetics of [(18)F]MK6240 and to investigate different strategies for in-vivo quantification of tau aggregates in humans. METHODS: Thirty-five...

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Publié dans:Eur J Nucl Med Mol Imaging
Auteurs principaux: Guehl, Nicolas J., Wooten, Dustin W., Yokell, Daniel L., Moon, Sung-Hyun, Dhaynaut, Maeva, Katz, Samantha, Moody, Kirsten A., Gharagouzloo, Codi, Kas, Aurélie, Johnson, Keith A., El Fakhri, Georges, Normandin, Marc D.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709592/
https://ncbi.nlm.nih.gov/pubmed/31332496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04419-z
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