18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy

Abstract Background Molecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated 18F-MK-6240 tau PET as a biomarker for CTE. Two studies were done: (1) 3H-MK-6240 autoradiography and an in-vitro brain homogenate binding studies on postmortem CTE tissue, (2) an in-vivo 18F...

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Autores principales:	Michael L. Alosco, Jhony Mejía Pérez, Julia E. Culhane, Ranjani Shankar, Christopher J. Nowinski, Samantha Bureau, Nidhi Mundada, Karen Smith, Alinda Amuiri, Breton Asken, Jenna R. Groh, Annalise Miner, Erika Pettway, Sydney Mosaheb, Yorghos Tripodis, Charles Windon, Gustavo Mercier, Robert A. Stern, Lea T. Grinberg, David N. Soleimani-Meigooni, Bradley T. Christian, Tobey J. Betthauser, Thor D. Stein, Ann C. McKee, Chester A. Mathis, Eric E. Abrahamson, Milos D. Ikonomovic, Sterling C. Johnson, Jesse Mez, Renaud La Joie, Daniel Schonhaut, Gil D. Rabinovici
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-02-01
Colección:	Molecular Neurodegeneration
Materias:	Alzheimer’s disease Biomarkers Chronic traumatic encephalopathy MK-6240 Repetitive head impacts Tau PET
Acceso en línea:	https://doi.org/10.1186/s13024-025-00808-1
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