Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major bacterial pathogen associated with a rising prevalence of antibiotic resistance. We evaluated the resistance mechanisms of P. aeruginosa against POL7080, a species-specific, first-in-class antibiotic in clinical trials that targets the lipopolysaccharide transport p...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Romano, Keith P., Warrier, Thulasi, Poulsen, Bradley E., Nguyen, Phuong H., Loftis, Alexander R., Saebi, Azin, Pentelute, Bradley L., Hung, Deborah T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709506/
https://ncbi.nlm.nih.gov/pubmed/31235628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00511-19
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