Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects

Tebipenem pivoxil hydrobromide (TBPM-PI-HBr, formerly SPR994) is an orally available prodrug of tebipenem, a carbapenem with activity versus multidrug-resistant (MDR) Gram-negative pathogens, including quinolone-resistant and extended-spectrum-β-lactamase-producing Enterobacteriaceae. The safety and...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Eckburg, Paul B., Jain, Akash, Walpole, Susannah, Moore, Grayson, Utley, Luke, Manyak, Erika, Dane, Aaron, Melnick, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709501/
https://ncbi.nlm.nih.gov/pubmed/31262768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00618-19
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