Time‐to‐Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine‐Citrulline‐Monomethylauristatin E Antibody–Drug Conjugates

Peripheral neuropathy (PN) is a common long‐term debilitating toxicity of antimicrotubule agents. PN was the most frequent adverse event resulting in dose modifications and/or discontinuation of treatment for valine‐citrulline‐monomethylauristatin E antibody–drug conjugates (ADCs) developed at Genen...

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Bibliographic Details
Published in:CPT Pharmacometrics Syst Pharmacol
Main Authors: Kågedal, Matts, Samineni, Divya, Gillespie, William R., Lu, Dan, Fine, Bernard M., Girish, Sandhya, Li, Chunze, Jin, Jin Y.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709423/
https://ncbi.nlm.nih.gov/pubmed/31207190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12442
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