The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal

Various antitumor drugs, including paclitaxel, frequently cause chemotherapy-induced peripheral neuropathy (CIPN) that can be sustained even after therapy has been completed. The current work was designed to evaluate R-47, an α7 nAChR silent agonist, in our mouse model of CIPN. R-47 was administered...

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Gepubliceerd in:Exp Neurol
Hoofdauteurs: Toma, Wisam, Kyte, S. Lauren, Bagdas, Deniz, Jackson, Asti, Meade, Julie A., Rahman, Faria, Chen, Zhi-Jian, Del Fabbro, Egidio, Cantwell, Lucas, Kulkarni, Abhijit, Thakur, Ganesh A., Papke, Roger L., Bigbee, John W., Gewirtz, David A., Damaj, M. I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708482/
https://ncbi.nlm.nih.gov/pubmed/31299179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113010
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