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Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets

Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more severe and less responsive to treatment in obese subjects. While alterations in mitochondrial function and redox signaling have been implicated in asthma pathogenesis, it is unclear whether these mechanisms differ in...

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Bibliographische Detailangaben
Veröffentlicht in:Antioxid Redox Signal
Hauptverfasser: Winnica, Daniel, Corey, Catherine, Mullett, Steven, Reynolds, Michael, Hill, Gabrielle, Wendell, Stacy, Que, Loretta, Holguin, Fernando, Shiva, Sruti
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708272/
https://ncbi.nlm.nih.gov/pubmed/30608004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2018.7627
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