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Half-intercalation stabilizes slipped mispairing and explains genome vulnerability to frameshift mutagenesis by endogenous “molecular bookmarks”
Some sixty years ago chemicals that intercalate between base pairs of duplex DNA were found to amplify frameshift mutagenesis. Surprisingly, the robust induction of frameshifts by intercalators still lacks a mechanistic model, leaving this classic phenomenon annoyingly intractable. A promising idea...
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| Pubblicato in: | Bioessays |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6707839/ https://ncbi.nlm.nih.gov/pubmed/31379009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201900062 |
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