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Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
Protein misfolding is linked to a wide array of human diseases(1,2). Protective cellular protein quality control (PQC) mechanisms evolved to selectively recognize misfolded proteins and limit their toxic effects(3-9). Here we examine how molecular chaperones and the ubiquitin (Ub)-proteasome system...
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| Udgivet i: | Nature |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6707801/ https://ncbi.nlm.nih.gov/pubmed/30429547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0678-x |
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