HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes

Malaria and babesiosis are bloodborne protozoan infections for which the emergence of drug-resistant strains poses a threat. Our previous phage display cDNA screens established the essentiality of Plasmodium falciparum signal peptide peptidase (SPP) in asexual development at the blood stage of malar...

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Publicat a:Biochem Biophys Res Commun
Autors principals: Schwake, Christopher, Baldwin, Michael R., Bachovchin, William, Hegde, Shreeya, Schiemer, James, Okure, Carolyn, Levin, Andrew E., Vannier, Edouard, Hanada, Toshihiko, Chishti, Athar H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707064/
https://ncbi.nlm.nih.gov/pubmed/31311649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.07.031
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