First Total Synthesis and Pharmacological Potential of a Plant Based Hexacyclopeptide

A new bioactive proline-rich cyclohexapeptide - diandrine C (6), previously isolated from whole plant of Drymaria diandra (Caryophyllaceae), was synthesized through coupling reactions of tetrapeptide unit Boc-Gly--Pro--Tyr--Trp-OH with dipeptide unit -Pro-Gly-OMe using N,N-diisopropylcarbodiimide (D...

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Detalhes bibliográficos
Publicado no:Iran J Pharm Res
Main Authors: Dahiya, Rajiv, Singh, Sunil, Varghese Gupta, Sheeba, Sutariya, Vijaykumar B., Bhatia, Deepak, Mourya, Rita, Chennupati, Suresh V., Sharma, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: Shaheed Beheshti University of Medical Sciences 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706746/
https://ncbi.nlm.nih.gov/pubmed/31531075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22037/ijpr.2019.1100643
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