Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism

Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. We investigated a role for integrin-linked kinase (ILK) in insulin-mediated cell survival in cultured neurons and differentiated R28 cells....

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Foilsithe in:Heliyon
Main Authors: Tan, Jacqueline, Digicaylioglu, Murat, Wang, Stacy X.J., Dresselhuis, Jonathan, Dedhar, Shoukat, Mills, Julia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706370/
https://ncbi.nlm.nih.gov/pubmed/31463398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e02294
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