Periostin-expressing cell-specific transforming growth factor-β inhibition in pulmonary artery prevents pulmonary arterial hypertension

Transforming growth factor beta (TGF-β) has been shown to play a critical role in pathogenesis of pulmonary arterial hypertension (PAH) although the precise role of TGF-β signaling remains uncertain. A recent report has shown that periostin (Pn) is one of the most upregulated proteins in human PAH l...

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Udgivet i:PLoS One
Main Authors: Seki, Mitsuru, Furukawa, Nozomi, Koitabashi, Norimichi, Obokata, Masaru, Conway, Simon J., Arakawa, Hirokazu, Kurabayashi, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705784/
https://ncbi.nlm.nih.gov/pubmed/31437169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220795
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