The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/β-Catenin Signaling

Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. Transcription factor 7-like 2 (TCF7l2), also known as TCF4, is a Wnt effector induced transiently in the oligodendroglial lineage. A well accepted dogma is that TCF7l2 inhibits oligod...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Hammond, Elizabeth, Lang, Jordan, Maeda, Yoshiko, Pleasure, David, Angus-Hill, Melinda, Xu, Jie, Horiuchi, Makoto, Deng, Wenbin, Guo, Fuzheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705374/
https://ncbi.nlm.nih.gov/pubmed/25810530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4787-14.2015
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