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Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2
NMNAT2 is an NAD(+)-synthesizing enzyme with an essential axon maintenance role in primary culture neurons. We have generated an Nmnat2 gene trap mouse to examine the role of NMNAT2 in vivo. Homozygotes die perinatally with a severe peripheral nerve/axon defect and truncated axons in the optic nerve...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6705152/ https://ncbi.nlm.nih.gov/pubmed/23946398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1534-13.2013 |
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