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Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons
The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival. Specific depletion of Nmnat2 is sufficient to induce Wallerian-like degener...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811159/ https://ncbi.nlm.nih.gov/pubmed/20126265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000300 |
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