Disruption of the Presynaptic Cytomatrix Protein Bassoon Degrades Ribbon Anchorage, Multiquantal Release, and Sound Encoding at the Hair Cell Afferent Synapse

Inner hair cells (IHCs) of the cochlea use ribbon synapses to transmit auditory information faithfully to spiral ganglion neurons (SGNs). In the present study, we used genetic disruption of the presynaptic scaffold protein bassoon in mice to manipulate the morphology and function of the IHC synapse....

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jing, Zhizi, Rutherford, Mark A., Takago, Hideki, Frank, Thomas, Fejtova, Anna, Khimich, Darina, Moser, Tobias, Strenzke, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704940/
https://ncbi.nlm.nih.gov/pubmed/23467361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3491-12.2013
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