Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

BACKGROUND & AIMS: Endothelial dysfunction plays an essential role in liver injury, yet the phenotypic regulation of liver sinusoidal endothelial cells (LSECs) remains unknown. Autophagy is an endogenous protective system whose loss could undermine LSEC integrity and phenotype. The aim of our st...

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Udgivet i:J Hepatol
Main Authors: Ruart, Maria, Chavarria, Laia, Campreciós, Genís, Suárez-Herrera, Nuria, Montironi, Carla, Guixé-Muntet, Sergi, Bosch, Jaume, Friedman, Scott L., Garcia-Pagán, Juan Carlos, Hernández-Gea, Virginia
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704477/
https://ncbi.nlm.nih.gov/pubmed/30367898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.10.015
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