Two distinct E3 ligases, SCF(FBXL19) and HECW1, degrade thyroid transcription factor 1 in normal thyroid epithelial and follicular thyroid carcinoma cells, respectively

Thyroid transcription factor 1 (TTF1) regulates the tissue-specific expression of genes. However, the molecular regulation of TTF1 in thyroid normal and carcinoma cells has not been revealed. Here we identify 2 distinct ubiquitin E3 ligases that are responsible for TTF1 degradation in normal thyroid...

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Gepubliceerd in:FASEB J
Hoofdauteurs: Liu, Jia, Dong, Su, Wang, Heather, Li, Lian, Ye, Qinmao, Li, Yanhui, Miao, Jiaxing, Jhiang, Sissy, Zhao, Jing, Zhao, Yutong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Federation of American Societies for Experimental Biology 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704452/
https://ncbi.nlm.nih.gov/pubmed/31238008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900415R
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