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Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease

Choline is critical for normative function of 3 major pathways in the brain, including acetylcholine biosynthesis, being a key mediator of epigenetic regulation, and serving as the primary substrate for the phosphatidylethanolamine N-methyltransferase pathway. Sufficient intake of dietary choline is...

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Publicat a:FASEB J
Autors principals: Alldred, Melissa J., Chao, Helen M., Lee, Sang Han, Beilin, Judah, Powers, Brian E., Petkova, Eva, Strupp, Barbara J., Ginsberg, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704451/
https://ncbi.nlm.nih.gov/pubmed/31180719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802669RR
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