Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2

We reveal by high-throughput screening that activating transcription factor 1 (ATF1) is a novel pluripotent regulator in human embryonic stem cells (hESCs). The knockdown of ATF1 expression significantly up-regulated neuroectoderm (NE) genes but not mesoderm, endoderm, and trophectoderm genes. Of no...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:FASEB J
المؤلفون الرئيسيون: Yang, Shang-Chih, Liu, Jan-Jan, Wang, Cheng-Kai, Lin, Yu-Tsen, Tsai, Su-Yi, Chen, Wei-Ju, Huang, Wei-Kai, Tu, Po-Wen A., Lin, Yu-Chen, Chang, Ching-Fang, Cheng, Chih-Lun, Lin, Hsuan, Lai, Chien-Ying, Lin, Chun-Yu, Lee, Yi-Hsuan, Chiu, Yen-Chun, Hsu, Chiao-Ching, Hsu, Shu-Ching, Hsiao, Michael, Schuyler, Scott C., Lu, Frank Leigh, Lu, Jean
التنسيق: Artigo
اللغة:Inglês
منشور في: Federation of American Societies for Experimental Biology 2019
الموضوعات:
Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704446/
https://ncbi.nlm.nih.gov/pubmed/31242772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800220RR
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