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Impaired Short-Term Plasticity in Mossy Fiber Synapses Caused by Mitochondrial Dysfunction of Dentate Granule Cells Is the Earliest Synaptic Deficit in a Mouse Model of Alzheimer's Disease
Alzheimer's disease (AD) in the early stages is characterized by memory impairment, which may be attributable to synaptic dysfunction. Oxidative stress, mitochondrial dysfunction, and Ca(2+) dysregulation are key factors in the pathogenesis of AD, but the causal relationship between these facto...
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| Publicado en: | J Neurosci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6703608/ https://ncbi.nlm.nih.gov/pubmed/22539855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0465-12.2012 |
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