Impaired Short-Term Plasticity in Mossy Fiber Synapses Caused by Mitochondrial Dysfunction of Dentate Granule Cells Is the Earliest Synaptic Deficit in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) in the early stages is characterized by memory impairment, which may be attributable to synaptic dysfunction. Oxidative stress, mitochondrial dysfunction, and Ca(2+) dysregulation are key factors in the pathogenesis of AD, but the causal relationship between these facto...

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Vydáno v:J Neurosci
Hlavní autoři: Lee, Sang Hun, Kim, Kyung-Ran, Ryu, Shin-Young, Son, Sungmin, Hong, Hyun Seok, Mook-Jung, Inhee, Lee, Suk-Ho, Ho, Won-Kyung
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703608/
https://ncbi.nlm.nih.gov/pubmed/22539855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0465-12.2012
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