Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy

Mutations in the small heat shock protein HSPB1 (HSP27) are causative for Charcot-Marie-Tooth (CMT) neuropathy. We previously showed that a subset of these mutations displays higher chaperone activity and enhanced affinity to client proteins. We hypothesized that this excessive binding property migh...

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Published in:J Neurosci
Main Authors: Almeida-Souza, Leonardo, Asselbergh, Bob, d'Ydewalle, Constantin, Moonens, Kristof, Goethals, Sofie, de Winter, Vicky, Azmi, Abdelkrim, Irobi, Joy, Timmermans, Jean-Pierre, Gevaert, Kris, Remaut, Han, Van Den Bosch, Ludo, Timmerman, Vincent, Janssens, Sophie
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703512/
https://ncbi.nlm.nih.gov/pubmed/22031878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3266-11.2011
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