Increased Monomerization of Mutant HSPB1 Leads to Protein Hyperactivity in Charcot-Marie-Tooth Neuropathy

Small heat shock proteins are molecular chaperones capable of maintaining denatured proteins in a folding-competent state. We have previously shown that missense mutations in the small heat shock protein HSPB1 (HSP27) cause distal hereditary motor neuropathy and axonal Charcot-Marie-Tooth disease. H...

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Detalhes bibliográficos
Main Authors: Almeida-Souza, Leonardo, Goethals, Sofie, de Winter, Vicky, Dierick, Ines, Gallardo, Rodrigo, Van Durme, Joost, Irobi, Joy, Gettemans, Jan, Rousseau, Frederic, Schymkowitz, Joost, Timmerman, Vincent, Janssens, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857091/
https://ncbi.nlm.nih.gov/pubmed/20178975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082644
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