Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

Liver X receptors (LXRs) regulate immune cell function and cholesterol metabolism, both factors that are critically involved in Alzheimer's disease (AD). To investigate the therapeutic potential of long-term LXR activation in amyloid-β (Aβ) peptide deposition in an AD model, 13-month-old, amylo...

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Publicat a:J Neurosci
Autors principals: Terwel, Dick, Steffensen, Knut R., Verghese, Philip B., Kummer, Markus P., Gustafsson, Jan-Åke, Holtzman, David M., Heneka, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703224/
https://ncbi.nlm.nih.gov/pubmed/21562267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6546-10.2011
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