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cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

The Alzheimer’s disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin binding adaptor protein, but its function in the nervous system is largely unknown. Loss of the Drosophila ortholog cindr enhances neurotoxicity of human Tau, which forms neurofibrillary tangle patholo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Rep
Hauptverfasser: Ojelade, Shamsideen A., Lee, Tom V., Giagtzoglou, Nikolaos, Yu, Lei, Ugur, Berrak, Li, Yarong, Duraine, Lita, Zuo, Zhongyuan, Petyuk, Vlad, De Jager, Philip L., Bennett, David A., Arenkiel, Benjamin R., Bellen, Hugo J., Shulman, Joshua M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703184/
https://ncbi.nlm.nih.gov/pubmed/31412248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.041
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