The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission

Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels but the role of metabolites in SV release is unclear. Here, we uncover a role for...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Ugur, Berrak, Bao, Huan, Stawarski, Michal, Duraine, Lita R., Zuo, Zhongyuan, Lin, Yong Qi, Neely, G. Gregory, Macleod, Gregory T., Chapman, Edwin R., Bellen, Hugo J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747319/
https://ncbi.nlm.nih.gov/pubmed/29281828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.005
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