The Pancreatic Cancer-Initiating Cell Marker CD44v6 Affects Transcription, Translation, and Signaling: Consequences for Exosome Composition and Delivery

Pancreatic cancer-initiating cells (PaCIC) express CD44v6 and Tspan8. A knockdown (kd) of these markers hinders the metastatic capacity, which can be rescued, if the cells are exposed to CIC-exosomes (TEX). Additional evidence that CD44v6 regulates Tspan8 expression prompted us to explore the impact...

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Publicat a:J Oncol
Autors principals: Sun, Hanxue, Rana, Sanyukta, Wang, Zhe, Zhao, Kun, Schnölzer, Martina, Provaznik, Jan, Hackert, Thilo, Lv, Qingjie, Zöller, Margot
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702834/
https://ncbi.nlm.nih.gov/pubmed/31485223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3516973
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