Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis

BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA(1–6)), and serves as an important mediator in inflammation. Previous studies have demonstrated that LPA-LPA(1) cascade contributes to arthritis and skin sclerosis. In...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Miyabe, Chie, Miyabe, Yoshishige, Nagai, Jun, Miura, Noriko N., Ohno, Naohito, Chun, Jerold, Tsuboi, Ryoji, Ueda, Hiroshi, Miyasaka, Masayuki, Miyasaka, Nobuyuki, Nanki, Toshihiro
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702724/
https://ncbi.nlm.nih.gov/pubmed/31429784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1973-0
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