FXR regulates intestinal cancer stem cell proliferation

Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5(+)) cancer...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Fu, Ting, Coulter, Sally, Yoshihara, Eiji, Oh, Tae Gyu, Fang, Sungsoon, Cayabyab, Fritz, Zhu, Qiyun, Zhang, Tong, Leblanc, Mathias, Liu, Sihao, He, Mingxiao, Waizenegger, Wanda, Gasser, Emanuel, Schnabl, Bernd, Atkins, Annette R, Yu, Ruth T, Knight, Rob, Liddle, Christopher, Downes, Michael, Evans, Ronald M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701863/
https://ncbi.nlm.nih.gov/pubmed/30794774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.036
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller