Antiproliferative and Antimigratory Effects of a Novel YAP–TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

[Image: see text] The Hippo pathway is an important regulator of cell growth, proliferation, and migration. TEAD transcription factors, which lie at the core of the Hippo pathway, are essential for regulation of organ growth and wound repair. Dysregulation of TEAD and its regulatory cofactor Yes-ass...

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Vydáno v:J Med Chem
Hlavní autoři: Smith, Sarah A., Sessions, Richard B., Shoemark, Deborah K., Williams, Christopher, Ebrahimighaei, Reza, McNeill, Madeleine C., Crump, Matthew P., McKay, Tristan R., Harris, Gemma, Newby, Andrew C., Bond, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701825/
https://ncbi.nlm.nih.gov/pubmed/30640473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01402
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