Antiproliferative and Antimigratory Effects of a Novel YAP–TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

[Image: see text] The Hippo pathway is an important regulator of cell growth, proliferation, and migration. TEAD transcription factors, which lie at the core of the Hippo pathway, are essential for regulation of organ growth and wound repair. Dysregulation of TEAD and its regulatory cofactor Yes-ass...

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Detalhes bibliográficos
Publicado no:J Med Chem
Principais autores: Smith, Sarah A., Sessions, Richard B., Shoemark, Deborah K., Williams, Christopher, Ebrahimighaei, Reza, McNeill, Madeleine C., Crump, Matthew P., McKay, Tristan R., Harris, Gemma, Newby, Andrew C., Bond, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701825/
https://ncbi.nlm.nih.gov/pubmed/30640473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01402
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