Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities remains poorly defined. Here, we explore immune cell components of islet inflammation and define their roles in regulating β cell function and proliferation. Islet inflammation in obese mice is dominated by ma...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Ying, Wei, Lee, Yun Sok, Dong, Yi, Seidman, Jason S., Yang, Meixiang, Isaac, Roi, BaeSeo, Jong, Yang, Bi-Huei, Wollam, Joshua, Riopel, Matthew, McNelis, Joanne, Glass, Christopher K., Olefsky, Jerrold M., Fu, Wenxian
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701710/
https://ncbi.nlm.nih.gov/pubmed/30595478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.12.003
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