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Presenilin 1 Regulates [Ca(2+)]i and Mitochondria/ER Interaction in Cultured Rat Hippocampal Neurons

Mutations in the presenilin 1 (PS1) gene are a major trigger of familial Alzheimer's disease (AD), yet the mechanisms affected by mutated PS1 causing cognitive decline are not yet elucidated. In the present study, we compared rat hippocampal neurons in culture, transfected with PS1 or with muta...

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Vydáno v:Oxid Med Cell Longev
Hlavní autoři: Korkotian, Eduard, Meshcheriakova, Anna, Segal, Menahem
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701405/
https://ncbi.nlm.nih.gov/pubmed/31467635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7284967
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