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Presenilin 1 Regulates [Ca(2+)]i and Mitochondria/ER Interaction in Cultured Rat Hippocampal Neurons

Mutations in the presenilin 1 (PS1) gene are a major trigger of familial Alzheimer's disease (AD), yet the mechanisms affected by mutated PS1 causing cognitive decline are not yet elucidated. In the present study, we compared rat hippocampal neurons in culture, transfected with PS1 or with muta...

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Publicado en:Oxid Med Cell Longev
Autores principales: Korkotian, Eduard, Meshcheriakova, Anna, Segal, Menahem
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701405/
https://ncbi.nlm.nih.gov/pubmed/31467635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7284967
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