Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is thought to play a significant role in the advancement to chronic kidney disease and contributes to the deposition of extracellular matrix proteins and renal fibrosis relating to diabetic nephropathy. METHOD: We studied the effect of Nrf2-HO-1...

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Detalhes bibliográficos
Publicado no:J Diabetes Res
Main Authors: Shin, Jong Ho, Kim, Kyeong Min, Jeong, Jin Uk, Shin, Jae Min, Kang, Ju Hyung, Bang, Kitae, Kim, Joo-Heon
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701369/
https://ncbi.nlm.nih.gov/pubmed/31467925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2510105
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