Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is thought to play a significant role in the advancement to chronic kidney disease and contributes to the deposition of extracellular matrix proteins and renal fibrosis relating to diabetic nephropathy. METHOD: We studied the effect of Nrf2-HO-1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Diabetes Res
Prif Awduron: Shin, Jong Ho, Kim, Kyeong Min, Jeong, Jin Uk, Shin, Jae Min, Kang, Ju Hyung, Bang, Kitae, Kim, Joo-Heon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701369/
https://ncbi.nlm.nih.gov/pubmed/31467925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2510105
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