The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

AIMS: Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes. We have recently shown that preserving H3K27 and H3K4 methylation using the lysine demethylase inhibitor GSK-J4 reduces cytokine-induced destruct...

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Vydáno v:J Diabetes Res
Hlavní autoři: Backe, Marie Balslev, Jin, Chunyu, Andreone, Luz, Sankar, Aditya, Agger, Karl, Helin, Kristian, Madsen, Andreas Nygaard, Poulsen, Steen Seier, Bysani, Madhusudhan, Bacos, Karl, Ling, Charlotte, Perone, Marcelo Javier, Holst, Birgitte, Mandrup-Poulsen, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701283/
https://ncbi.nlm.nih.gov/pubmed/31467927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/5451038
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