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Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer
BACKGROUND: Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune landscape relates to different aspects of the CRC’s biology...
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| 出版年: | J Exp Clin Cancer Res |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6701076/ https://ncbi.nlm.nih.gov/pubmed/31429779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1372-z |
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