Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

BACKGROUND: Microsatellite unstable colorectal cancers (MSI+ CRCs) expressing PD-L1, respond to anti-PD-1 or anti-PD-L1 checkpoint blockade, whereas microsatellite-stable tumors do not respond the same. Our aim was to examine how the immune landscape relates to different aspects of the CRC’s biology...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Zaravinos, Apostolos, Roufas, Constantinos, Nagara, Majdi, de Lucas Moreno, Beatriz, Oblovatskaya, Maria, Efstathiades, Christodoulos, Dimopoulos, Christos, Ayiomamitis, Georgios D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701076/
https://ncbi.nlm.nih.gov/pubmed/31429779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1372-z
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