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Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism

Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this can mislead models because up to 40% of the intracellular volume—depending on the organism, the physiology, and the cellular compartment—is...

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Pubblicato in:Biophys J
Autori principali: Weilandt, Daniel R., Hatzimanikatis, Vassily
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701012/
https://ncbi.nlm.nih.gov/pubmed/31311624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.06.017
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