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Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism

Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this can mislead models because up to 40% of the intracellular volume—depending on the organism, the physiology, and the cellular compartment—is...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Weilandt, Daniel R., Hatzimanikatis, Vassily
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701012/
https://ncbi.nlm.nih.gov/pubmed/31311624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.06.017
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