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Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism
Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this can mislead models because up to 40% of the intracellular volume—depending on the organism, the physiology, and the cellular compartment—is...
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| Gepubliceerd in: | Biophys J |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Biophysical Society
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6701012/ https://ncbi.nlm.nih.gov/pubmed/31311624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.06.017 |
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